| Pair Name | Nimbolide, Tumor necrosis factor-alpha | ||
| Phytochemical Name | Nimbolide (PubChem CID: 12313376 ) | ||
| Anticancer drug Name | Tumor necrosis factor-alpha (PubChem CID: / ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Nimbolide, Tumor necrosis factor-alpha | |||
| Disease Info | [ICD-11: 2B90.Z] | Colon cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Down-regulation | Expression | BID | hsa637 |
| Up-regulation | Cleavage | CASP3 | hsa836 | |
| Up-regulation | Phosphorylation | MAPK8 | hsa5599 | |
| Up-regulation | Expression | TNFRSF10B | hsa8795 | |
| In Vitro Model | HT-29 | Colon adenocarcinoma | Homo sapiens (Human) | CVCL_0320 |
| Result | Our findings overall indicate that nimbolide may enhance TNF-α-mediated cellular proliferation inhibition through increasing cell apoptosis of HT-29 cells by up-reglation of DR5 expression via the JNK pathway. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Combination of Nimbolide and TNF-α-Increases Human Colon Adenocarcinoma Cell Death through JNK-mediated DR5 Up- regulation. Asian Pac J Cancer Prev. 2016;17(5):2637-41. | Click |
